SUBSTITUTIONS OF THE 3- AND 5-IODO GROUPS
Analog 2

• The 3-iodo group has been replaced with a 3-t-butyl group, [(CH₃)₃C-].  As with the other compounds, this is the side view of the molecule.
• Using the bottom and right rotation bars, observe the rear and overhead views.
• QUESTION 3:  Judging by what you see on the screen and what you have learned in this exercise, how would you expect the activity of this thyroid analog to compare with the activity of thyroxine?
• As with analog 1, some students may wish to rotate about the O[1]-C[2] bond.  To do this switch to Ball and Stick mode, click the O[1] atom, verify that a white ring highlights the O[1] atom, switch back to the Space Filling mode,  rotate about the selected bond using the left rotation bar, and again examine the overhead, side and rear views.

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