Curriculum Vitae
Paula Ann Witt-Enderby, Ph.D.
Professor of Pharmacology and Toxicology
President, Faculty Senate
Office Address: Duquesne University
Division of Pharmaceutical Sciences
School of Pharmacy
Mellon Hall of Science
Pittsburgh, PA 15282
(412) 396-4346
fax (412) 396-5599
email wittp@duq.edu
pharmacy web page: http://www.pharmacy.duq.edu/witt-Enderby.html
personal web page: http://www-home.cr.duq.edu/~wittp/
Education
08/89-08/93, Ph.D. Pharmacology and Toxicology, Graduate Program in Pharmacology and Toxicology, University of Arizona, Tucson, AZ.
08/84-05/88, B.S., Biochemistry, Department of Biochemistry, University of Illinois at Urbana-Champaign, IL.
Postdoctoral Training
01/95-08/96, Postdoctoral Fellow, Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, IL. Sponsor: Dr. Margarita Dubocovich
10/93- 01/95, Postdoctoral Fellow, Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, IL. Sponsor: Dr. Marlene Hosey
Professional appointments
07/08-present, Professor of Pharmacology and Toxicology, Division of Pharmaceutical Sciences, School of Pharmacy, Duquesne University.
10/06-present, Adjunct Assistant Professor, Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Women’s Hospital, University of Pittsburgh, Pittsburgh, PA
09/06-03/07, Sabbatical in Dr. Jean Latimer’s laboratory, Hillman Cancer Institute, University of Pittsburgh
08/02-05/06, Head, Pharmacology and Toxicology Group within the Division of Pharmaceutical Sciences, Duquesne University
07/02-06/08, Associate Professor and Head of Pharmacology and Toxicology, Division of Pharmaceutical Sciences, School of Pharmacy, Duquesne University
08/96-06/02, Assistant Professor of Pharmacology and Toxicology, Division of Pharmaceutical Sciences, School of Pharmacy, Duquesne University.
Awards and Honors
2008, Advisor of the Year, Kappa Epsilon, Inc, Professional Pharmacy Fraternity
2008, Faculty Award for Sustained Excellence in Teaching, Research and Service, School of Pharmacy, Duquesne University
2008-present, The Honor Society of Phi Kappa Phi, Duquesne University
2007, Presidential Award for Excellence in Service to the Mission, Duquesne University. Please see link to Tribune Review: http://www.pittsburghlive.com/x/leadertimes/sports/s_527161.html
2007, Excellence in Service Award, School of Pharmacy
2006-2008, President of the Faculty Senate, Duquesne University
2008, Susan G. Komen Grant Reviewer for Translational Research study section
2006, 2007, Susan G. Komen Grant Reviewer for Tumor Biology IV study section
2006-present, Phi Lambda Sigma Pharmacy Leadership Society
2006, Served as an external reviewer for promotion and tenure at McGill University, Canada
2005-present, Advisor, Pharmacy Class of 2011
2004-2006, Vice President of the Faculty Senate, Duquesne University
2004, Acting President of the Faculty Senate, Duquesne University
2003, Teacher of the Year, American Association of Colleges of Pharmacy (124 professors awarded nationwide)
2003, Voted Best Teacher in the School of Pharmacy (TOPs Award) by the 6th year Pharmacy Students
2003, Excellence in Service Award, Division of Pharmaceutical Sciences, Duquesne University School of Pharmacy.
2000,2001,2002 National Chain of Pharmacy Association Members’ Favorite Professor
1999, 2000, 2001,2002 Nominated Teacher of the Year by Duquesne’s Chapter of Omicron Delta Kappa National Leadership Honor Society
1997-present, Advisor, Kappa Epsilon Professional Female Pharmacy Fraternity, Alpha Phi Chapter
1997, Who’s Who in Science and Engineering
1996-2006, Chair of Biological Sciences, Carnegie Science Fair
1996-present, Rho Chi Professional Honor Society for Pharmacy
1992-1993, Ethics Committee Representative for the Graduate Program in Pharmacology and Toxicology, University of Arizona, Tucson, AZ.
1992-1993, Graduate Student Representative for the Graduate Program in Pharmacology and Toxicology, University of Arizona, Tucson, AZ.
1990, Collegiate Leadership Institute Certificate for Graduate Program in Pharmacology and Toxicology, University of Arizona, Tucson, AZ.
1988, Outstanding College Student of America
Biotechnology
March, 2007, Commercialization of recombinant cell lines expressing human melatonin receptors to Genway Biotech, Inc., San Diego, CA
Grant Support
12/01/08-11/30/13, “Impact of Prenatal Melatonin, a Bioactive Component of Cherries, and Light Pollution on Mammary Tumor Development”, National Institutes of Health, PI, 1,250,000 (pending)
05/01/08-04/30/11, “Serotonergic Therapies Influence on Mammary Tumorigenesis and Progression.” Co-PI, $600,000 (pending)
05/01/08-04/30/11, “Assessing the efficacy and mechanisms of Morinda citrifolia (Noni) on
mammary tumor promotion and progression in a HER2/neu mouse model". PI, $330,000 (pending)
01/01/08-12/31/09, “The Effect of Melatonin on Bone Turnover Markers in Perimenopausal Women”, Translational Research Grant, Duquesne University. PI. $20,000.
01/01/08-12/31/10, “Development of a Bone-regenerative Scaffold” $42,274, Pennsylvania Department of Health.
05/01/07-04/3008, “Pharmacological Evaluation of 13a, 14 dihydro-6H-pyrazino[1,2-a;4,5-a’]diindole Analogs as Melatonin Receptor Ligands Using Competition Binding Analysis and Recombinant Cell Lines Expressing the Human MT1 and MT2 Melatonin Receptors” American Foundation for Pharmaceutical Education, “5000. This was a scholarship that my pharmacy student, Justin Julius, was awarded to work on a research project in my lab.
07/01/06-06/30/08, “The Effect of Melatonin’s Efficacy at Reducing Primary and Metastatic Breast Cancer Risk”, Susan G. Komen Breast Cancer Foundation $250,000, PI.
09/01/04-08/31/06, “Elucidating the Role that Melatonin and Its Receptors Play in the Differentiation of Human Adult Mesenchymal Stem Cells into Osteoblasts”, American Foundation for Pharmaceutical Education, $12,000. This was a scholarship that my doctoral student, Nick Radio, was awarded to supplement his stipend for the year.
02/01/04-01/31/05, “Structural Motifs Underlying G protein-coupled Receptor Function”, Pennsylvania Health Assessment Fund, $29,000 (Collaborating Investigator, $13,000).
05/01/03-04/30/02, “Acquisition of a Confocal Microscope”, National Science Foundation, $185,890 (Participating Member).
01/01/02-12/31/03, “Characterization of Melatonin’s Role in Differentiating Human Osteoblasts”, Pennsylvania Health Research Formula Fund $34,193.
06/01/02 - 05/31/03, “The Effect of Microtubule Depolymerization in the SCN of the Hypothalamus on the Entrainment of Circadian Rhythms in the Free-running Rat”, Faculty Development Fund, Duquesne, University $10,000.
08/01/00-12/31/03, #R15NS38873 “Development of Melatonin Receptor Ligands”, National Institute of Neurological Disorders and Stroke, Academic Research Enhancement Award $25,000 (Collaborating Investigator).
04/23/99-03/31/02, #R15DK54070 “Mechanisms Underlying Melatonin Receptor Function”, National Institute of Diabetes and Digestive and Kidney Diseases, Academic Research Enhancement Award $92,613.
09/01/01-08/31/02, “The Role of Microtubules in Melatonin Receptor Function”, American Foundation for Pharmaceutical Education, $6,000. This was a scholarship that my doctoral student, Mick Jarzynka, was awarded to supplement his stipend for the year.
04/01/99 – 03/31/00, “The Development of Melatonin Receptor Ligands”, Hunkele Foundation Dreaded Disease Award $10,000.
07/01/97 - 06/30/98, Faculty Development Award, Department of Pharmacology and Toxicology, Mylan School of Pharmacy, Duquesne, University, “Mechanisms Underlying Melatonin Function in CHO Cells”, $5000.
1993-1996, #F32 HL08965 Individual NIH National Research Science Award, Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, IL.
1990-1991, Lilly Predoctoral Fellowship, Department of Pharmacology, University of Arizona, Tucson, AZ.
1990, Graduate Student ASPET Award (American Society for Pharmacology and Experimental Therapeutics).
1989-1990, Graduate Training Fellowship from the Department of Pharmacology, University of Arizona, Tucson, AZ.
board of directors
1997-2003, Collegiate Young Men’s Christian Assocation of Pittsburgh (YMCA)
2003-2006, International Editorial Advisory Board for Life Sciences Journal
Committees
National
07/01/99-06/31/05- Subcommittee on the Graduate Student Convocation of the Committee on Education for the American Society for Pharmacology and Experimental Therapeutics (ASPET).
06/01/01-present-Systems and Integrative Pharmacology Division, American Society for Pharmacology and Experimental Therapeutics
Internal (University)
1996-1997, Academic Tenure and Freedom Committee, Faculty Senate.
1998-2005, Radiation Safety Committee
2002, Dean’s Evaluation Committee
2002-2003, Faculty Senate Executive Committee
2003, Student Grievance Committee
2004-present, President’s Insight Group
20042005, President’s Advisory Board
2004, Dean’s Advisory Committee
2004, 2005-present Honors and Awards Committee
2005-2008, Middle States Self Study Steering Committee
2006-2008, Chair, Subcommittee on Faculty Standard for Middle States Accreditation
2005-2006, University Advisory Council
2005-2006, Dean’s Search Committee for School of Pharmacy
2006-2007, Security Task Force
2006-present, University Budget Committee
2006-2008, President, Faculty Senate
2008-2010, President, Faculty Senate
2006-present, Academic Council
2008, Faculty Excellence Awards Committee
2008, Five-year Strategic Planning Committee
Internal (School of Pharmacy)
1996-2006, Faculty Development Committee.
1998-2004, Pharmacy Safety Committee.
2001-2002, Scholarship Committee
2001-2002, Case Studies Committee
1997-2001, Curriculum Committee (ad hoc), Department of Pharmacology and Toxicology.
2001-2006, Curriculum Committee
2001-2002, Graduate School Policies and Procedures Committee (Chair)
2001-2003, Graduate School Admissions Committee
2003-2006, Graduate Council
2004, Dean’s Evaluation Committee
2004, Competency Assessment Examination Committee
2004. Pharmacology/Toxicology Faculty Search Committee (Chair)
2005-2006, Pharmacology/Toxicology Faculty Search Committee
2006-2007, Promotion and Tenure Committee in Division of Pharmaceutical Sciences
2005-2005, ACPE Self-Study Subcommittee on Faculty and Administrative Relationships
2008, Graduate School of Pharmaceutical Sciences Strategic Planning Committee
Continuing Education
March 15, 2007, Attended a workshop entitled “Skinning the Drum: teaching about diversity as ‘other’”, Center for Teaching Excellence, Duquesne University.
April 17, 2004, Organized a symposium entitled: 2004 Teaching Institute: Strategies for Collaborative/Integrative Teaching and Research Relationships Between Pharmaceutical Sciences and Pharmacy Practice Facilities for ASPET, 2004.
1999-present, Melatonin Journal Club (International on-line)
1998-present, Department of Cell Biology and Physiology and Center for Research in Reproductive Physiology, University of Pittsburgh, Oakland, PA.
1997-present, Pittsburgh Tissue Engineering Initiative Seminar Series
March 25, 1997, The Professor’s Guide to Integrating Writing, Critical Thinking, and Active Learning in the Classroom.
March 30, 1997, “Classroom Assessment Techniques: A Handbook for College Teachers and Engaging Ideas”
November 5, 1997, “How to Deal with Troublesome Students”
May 12-13, 1997, “Teaching Effectively with Cases”
March 31, 1998, “Preparing an Effective Case for Third-Year Review, Promotion and Tenure”.
1993-1996, Signal Transduction Journal Club, Northwestern University Medical School, Chicago, IL. Participate in discussions and present papers relevant in the area of signal transduction.
1994-1995, MPBC Postdoctoral Seminar Series Committee (Member). Invite and host seminar speakers. Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, IL.
1995-1996, MPBC Postdoctoral Seminar Series Committee (Group Coordinator). Duties include selecting and supervising postdoctoral fellows in determining the year's areas of seminar topics and on inviting the speakers, Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, IL.
1995, Molecular Modelling Workshop, Participated in a 2-day workshop to learn the fundamentals of molecular modelling of receptors using computer programs (HOMOLOGY), Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, IL.
1995-1996, Melatonin and Light Journal Club, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL. Participate in discussions and present papers relevant to the melatonin receptor field.
1997, Book Study Groups, Duquesne University, Pittsburgh, PA. Classroom Assessment Techniques: A Handbook for College Teachers and Engaging Ideas: The Professor’s Guide to Integrating Writing, Critical Thinking, and Active Learning in the Classroom.
Languages: English and Spanish
Membership
1989-present, Society for Neuroscience
1996-present, American Association of Colleges of Pharmacy
1997-present, American Society for Pharmacology and Experimental Therapeutics
2006-present, University of Pittsburgh Cancer Institute Cancer Stem Cell Biology Program
2006-present, Center for Environmental Oncology, University of Pittsburgh
Students and Postdoctoral Fellows Supervised
(*indicates students who received graduate degrees under my advisement)
Summer, 1995, JaChan Campbell, Medical Scholar for The Chicago Area Health and Medical Summer Preceptorship Program and The Pathway to Medical Education Preceptorship Program, Northwestern University Medical School.
Summer, 1995, Nicolle Martin, Medical Scholar for The Chicago Area Health and Medical Summer Preceptorship Program and The Pathway to Medical Education Preceptorship Program, Northwestern University Medical School. Currently, is a 3rd year medical student.
10/95-12/95, Bijan Mossadeghi, Ph.D. Graduate Student in Neuroscience, Northwestern University Medical School.
10/95-3/96, Eve Balint, M.D., Postdoctoral Fellow, Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School.
09/96-12/96, Charles Shea, Pharmacy Student, School of Pharmacy, Duquesne University. Currently, is a practicing pharmacist.
*09/96-12/97, Renee MacKenzie, M.S. Graduate Student, Department of Pharmacology and Toxicology, Duquesne University. Currently, is completing her Pharm.D. degree.
*09/96-06/98, Marla Jones, Ph.D. Graduate Student, Department of Pharmacology and Toxicology, Duquesne University.
09/96-08/98, Jan Seng, M.S. Graduate Student, Department of Biological Sciences, Duquesne University.
01/96-08/97, Megan Gillen, Ph.D. Graduate Student, Department of Pharmacology and Toxicology, Duquesne University.
06/97-08/97, Emily Weiss, Pittsburgh Tissue Engineering Initiative Program Scholar, Pittsburgh, PA. Currently, is a student in Chemistry at Princeton University.
09/97-12/97, Sharon Gannon, B.S. Pharmacy Student, Duquesne University, Pittsburgh, PA.
05/97-10/97, Joerg Brockmann, Pharmacy Student, University of Wuerzburg, Germany. Currently is a doctoral student in the laboratory of Dr. Lohse, Wuerzburg, Germany.
09/98-05/00, Ann Gorman, Pharm.D./B.S. Pharmaceutical Sciences, Graduate School of the Pharmaceutical Sciences and Mylan School of Pharmacy, Duquesne University.
06/99-08/00, Shannon Bordt, Physicians Assistant Student in the Rangos School of the Health Sciences, Duquesne University.
*09/97-05/03, Michael Jarzynka, R.Ph, Ph.D.., Graduate Student, Department of Pharmacology and Toxicology, Duquesne University. Currently, is a postdoctoral fellow at the University of Pittsburgh Cancer Institute.
05/98-09/02, B. Justin Krawitt, Masters Graduate Student, Department of Pharmacology and Toxicology, Duquesne University.
*01/00 – 05/03, Deepshikha K. Passey, M.S., Masters Graduate Student, Department of Pharmacology and Toxicology, Duquesne University. Currently is seeking board certification to practice pharmacy in the U.S..
06/00 – 07/01, Paul Ignatius, B.S. Biology Student, Davidson College, Davidson, North Carolina.
01/01-12/01, Paul Malichky, M.S, Doctoral Student at Duquesne University, Pittsburgh, PA.
06/01-09/01, Robert Kaufman, Pharm.D. Student, Duquesne University School of Pharmacy, Pittsburgh, PA.
05/01-08/01, Ismail Yousef, Pharm.D. Student, Duquesne University, School of Pharmacy Pittsburgh, PA.
05/00-08/01, Jennifer Bennett, Masters Graduate Student, Department of Biology, Duquesne University.
*09/02-09/06, Corry Bondi, Masters Graduate Student, Division of Pharmaceutical Sciences, Duquesne University.
*09/02-05/06, Nick Radio, Ph.D. Doctoral Graduate Student, Division of Pharmaceutical Sciences, Duquesne University.
01/03-04/06, Nagarjun Konduru, Masters Graduate Student, Division of Pharmaceutical Sciences, Duquesne University.
06/03-08/03 and 06/04-08/04, Aksana Vasilyeva, Summer Undergraduate Research Program (SURP) student., College of St. Elizabeth, Morristown, NJ.
*09/04-present, Shalini Sethi, Doctoral Graduate Student, Division of Pharmaceutical Sciences, Duquesne University.
*09/06-03/09, William Clafshenkel, M.S Masters Graduate, Division of Pharmaceutical Sciences, Duquesne University
05/06-05/09, Justin Julius, Pharm.D., Duquesne University. Resident Fellow, M.D. Anderson
09/06-08/08, Tracy King, Pharm.D. Fellow in Academic and Research Fellow, Duquesne University Residency Program.
01/07-present, Bala Sunder Reddy, Masters Graduate Student, Division of Pharmaceutical Sciences, Duquesne University
06/07-08/08, Lawrence Blume, Summer Undergraduate Research Program (SURP) student., Department of Biology, Duquesne University.
*08/08-present, Corry Bondi, Doctoral Graduate Student, Division of Pharmaceutical Sciences, Duquesne University.
03/09-present, William Clafshenkel, Doctoral Graduate Student, Division of Pharmaceutical Sciences, Duquesne University
08/08-present, Mary Kotlarczyk, Doctoral Graduate Student, Division of Pharmaceutical Sciences, Duquesne University
Teaching Experience
1997-present (Course Master), GPHSC 570: Drug Mechanisms (lecture), Duquesne University, Mylan School of Pharmacy, Attendance: 15 masters and doctoral students in the Graduate School of Pharmaceutical Sciences.
1999-present, GPHSC 672: Advanced Pharmacology I, Duquesne University, Mylan School of Pharmacy, Attendance: 4 doctoral candidates in the Department of Pharmacology and Toxicology.
2002-present, GPHSC 673: Advanced Pharmacology II, Duquesne University, Mylan School of Pharmacy, Attendance: 6 doctoral candidates in the Department of Pharmacology and Toxicology.
2006, 2008 PHPR 464: Palliative Care, Attendance: Approximately 10 sixth year pharmacy students. This is an elective offered to sixth year pharmacy students. I taught three lectures in tandem with Dr. Mihalyo on mechanisms underlying pain and pain management.
1997-2001 (Course Master), GPHSC 693 & 694: Seminar for the graduate students in the Department of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Duquesne University, Attendance: 12 graduate students.
1999-present PHMBS 425 (Course Master in 2007): Biomedical Sciences and Therapeutics IV, Pathophysiology and pharmacology of endocrine disorders and drugs, Attendance: 200 fifth year pharmacy students.
2008-present PHMBS 425-71 (Course Master): Biomedical Sciences and Therapeutics IV, Pathophysiology and pharmacology of endocrine disorders and drugs, Attendance: 20 fifth year weekend pharmacy students.
1997-2001 (Course Master), PHINT 390: Integrated Case Studies, Duquesne University, Mylan School of Pharmacy, Attendance: 25 third year pharmacy students.
1997-present, (Course Master) PHBMS 355 & 356: Human Physiology I and II (lecture/laboratory), Duquesne University, Mylan School of Pharmacy. Attendance: 195 third year pharmacy students.
1997, BIO 339: Pharmacology (lecture), Carlow College, Pittsburgh PA. Attendance: 9 nurses in the B.S. of nursing program.
1996, PHBMS 322: Drug Mechanisms II (lecture), Duquesne University, Mylan School of Pharmacy. Attendance: 160 fourth year pharmacy students.
1996-present, GPHSC 572: Methods in Pharmacology (lecture/laboratory), Duquesne University, Department of Pharmacology/Toxicology, School of Pharmacy, Attendance: 10 Graduate Students in the School of Pharmaceutical Sciences.
2004-present, GPHSC 513: Principles of Drug Action, Design and Delivery, Duquesne University, Graduate School of Pharmaceutical Sciences, School of Pharmacy, Attendance: 12 Graduate students in the Graduate School of Pharmaceutical Sciences.
1995, Cardiology Course (medical school course and course for postgraduate cardiologists and general practitioners), Childrens Memorial Hospital, Northwestern University, Attendance: cardiologists and medical students.
1995, The Chicago Area Health and Medical Summer Preceptorship Program and The Pathway to Medical Education Summer Preceptorship Program.
Grant review committees
1998-2000, Pittsburgh Tissue Engineering Initiative Seed Grant Program
2001-2005, Institutional Summer Undergraduate Fellowships (ASPET SURF Awards)
2006, 2007, Susan G. Komen Breast Cancer Foundation Grant Review Panel (Tumor Biology IV).
2007-2008, Susan G. Komen for the Cure Grant Review Panel (Investigator Initiated Research and Career Catalyst Research Cellular Molecular Biology and Genetics 3, MCBG-3)
reviews
Textbook reviewed Tortora’s Principles of Anatomy and Physiology (11th ed). John Wiley & Sons.Publishers (Invited).
Textbook reviewed Essentials of Pathophysiology: Concepts and Applications for Health Care Professionals by Nowack and Hanford (2nd ed). Wm. C. Brown Publishers (Invited).
Witt-Enderby, P.A. and Li, P.K, Melatonin Receptors and Ligands InVitamins and Hormones 58: 321-354 (2000). Invited
Li, P.K. and Witt-Enderby, P.A., Melatonin Receptors as Targets for Drug Discovery, In Drugs of the Future, 25(9): 945-957 (2000). Invited
Witt-Enderby, P.A., Bennett, J., Jarzynka, M.J., Firestine, S. and Melan, M.A. Melatonin Receptors and their Regulation: Biochemical and Structural Mechanisms In Life Sciences, 72(2): 2183-2198 (2003). Invited
Witt-Enderby, P.A., Radio, N.M., Doctor, J.S, and Davis, V.L.. MINIREVIEW
Therapeutic Treatments Potentially Mediated by Melatonin Receptors: Potential Clinical Uses in the Prevention of Osteoporosis, Cancer and as an Adjuvant Therapy
In Journal of Pineal Research, 41 (4): 297- 305, 2006.
Grant, S.G., Melan, M.A., Latimer, J.J., and Witt-Enderby, P.A..Melatonin and Breast Cancer: Cellular Mechanisms, Clinical Studies and Future Perspectives In Expert Reviews in Molecular Medicine, 11: e5, 2009.
Science Features
“Many Paths to Choose: Careers in Cancer Research” by Julie Clayton, Science, April 6, 2007. http://sciencecareers.sciencemag.org/career_magazine/previous_issues/articles/2007_04_06/science.opms.r0700029
“The Cure: Western Pa. Has Become an Important Player in the Fight to Stop Cancer” by Allison M. Heinrichs. Monday, May 7, 2007. (also in video)
http://pittsburghlive.com/x/pittsburghtrib/news/cityregion/s_506093.html
“Duquesne Study Aims to Curb Bone Loss” by Luis Fabregas, Monday, March 23, 2009
http://www.pittsburghlive.com/x/pittsburghtrib/news/cityregion/s_617308.html
Publications
Lark, L.A., Witt, P.A., Becker, K.B., Studzinski, W.M., and Weyhenmeyer, J.A.: Effect of Dietary Tryptophan on the Development of Hypertension in the Dahl Salt-Sensitive Rat, Clinical and Experimental Hypertension, 12 (1) 1-13, 1990.
Witt, P.A., Kramer, T.H., and Burks, T.F.: ATP and Norepinephrine are Synergistic in the Mouse Vas Deferens Preparation, European Journal of Pharmacology, 304: 149-155, 1991.
Witt-Enderby, P.A., Yamamura, H.I., Halonen, M., Palmer, J.D., and Bloom, J.W.: Chronic Exposure to a b2-adrenoceptor Agonist Increases the Airway Response to Methacholine, European Journal of Pharmacology, 241: 121-123, 1993.
Witt-Enderby, P.A., Yamamura, H.I., Halonen, M.H., Lai, J., Palmer, J.D., and Bloom, J.W.: Regulation of Airway Muscarinic Cholinergic Receptor Subtypes by Chronic Anticholinergic Treatment, Molecular Pharmacology, 47: 485-490, 1995.
Pals-Rylaarsdam, R., Xu, Y., Witt-Enderby, P., Benovic, J.L. and Hosey, M.: Desensitization and Internalization of the m2 Muscarinic Acetylcholine Receptor are Directed by Independent Mechanisms and Receptor Domains, Journal of Biological Chemistry, 270 (48): 29004-29011, 1995.
Witt-Enderby, P.A. and Dubocovich, M.L.: Characterization and Regulation of the Human ML1A Melatonin Receptor in CHO Cells, Molecular Pharmacology, 50: 166-174, 1996.
Li, P.K., Chu, G-H., Gillen, M.L, and Witt-Enderby, P.A.: Synthesis and Receptor Binding Studies of Quinolinic Derivatives as Melatonin Receptor Ligands. Bioorganic Medicinal Chemistry Letters, 7: 2177-2180, 1997.
Li, P.K., Chu, G-H., Gillen, M.L., Parekh, T., and Witt-Enderby, P.A.: The Development of a Charged Melatonin Receptor Ligand. Bioorganic Medicinal Chemistry Letters, 7: 2409-2414, 1997.
Witt-Enderby, P.A., Chu, G.H., Gillen, M.L., and Li, P.K.: The Development of a High-Affinity Ligand that Binds Irreversibly to Mel1b Melatonin Receptors. Journal of Medicinal Chemistry Letters, Rapid Communication, 40: 4195-4198, 1997.
Witt-Enderby, P.A., Masana, M.I., and Dubocovich, M.L.: Physiological Exposure to Melatonin Supersensitizes the Cyclic Adenosine 3’,5’- Monophosphate-Dependent Signal Transduction Cascade in Chinese Hamster Ovary Cells Expressing the Human mt1 Melatonin Receptor. Endocrinology, 139: 3064 - 3071, 1998.
Jones, M.P., Melan, M.A. and Witt-Enderby, P.A.: Melatonin Decreases Cell Proliferation and Transformation in a Melatonin Receptor-Dependent Manner, Cancer Letters, 151: 133-143, 2000.
Witt-Enderby, P.A., MacKenzie, R.S., Carroll, E.A., Bordt, S.L., and Melan, M.A. “Melatonin Induction of Neurite-Like Structures in Non-neuronal Cells that is Dependent on Expression of the Human mt1 Melatonin Receptor. Cell Motility and the Cytoskeleton, 46: 28-42, 2000.
Bordt, S.L, McKeon, R.M, Li, P.K., Witt-Enderby, P.A., and Melan, M.A.: N1E115 Mouse Neuroblastoma Cells Express mt1 Melatonin Receptors and Produce Neurites in Response to Melatonin. Biochimica et Biophysica Acta. 1499: 257-264, 2001.
Clemens, J.W., Jarzynka, M.J., and Witt-Enderby, P.A., Down-regulation of mt1 melatonin receptors in rat ovary following estrogen exposure, Life Sciences 69(1): 27-35, 2001.
Chu, G-A., Witt-Enderby, P.A., Jones, M.P., and Li, P-K.: Synthesis and Pharmacological Analysis of High-Affinity Melatonin Receptor Ligands, Chemical and Pharmaceutical Bulletin, 50(2): 272-275, 2002.
MacKenzie, R.S. , Melan, M.A., Deepshikha K. Passey and Witt-Enderby, P.A.: Dual Coupling of MT1 and MT2 Melatonin Receptors to Cyclic AMP and Phosphoinositide Signal Transduction Cascades and Their Regulation Following Melatonin Exposure. Biochemical Pharmacology 63(4): 587-595, 2002.
Masana, M.I., Witt-Enderby, P.A. and Dubocovich, M.L.: Melatonin Differentially Modulates the Expression and Function of the hMT1 and hMT2 Melatonin Receptors Upon Prolonged Withdrawal. Biochemical Pharmacology 65: 731-739, 2003.
Witt-Enderby, P.A. and McFalls-Stringert, M.A.: The Integration of Basic Cell Biology Concepts into the Practice of Pharmacy. American Journal of Pharmaceutical Education [online serial] 68(2): Article 40, 2004.
El-Sherif, Y., Witt-Enderby, P.A., Li, P.K., Tesoriero, J., Hogan, M.V., and Wieraszko, A.: The Actions of A Charged Melatonin Receptor Ligand, TMEPI, and an Irreversible MT2 Receptor Agonist, BMNEP, on Mouse Hippocampal Evoked Potentials in Vitro, Life Sciences 75: 3147-3156, 2004.
Witt-Enderby, P.A., Krawitt, B.J., Jarzynka, M.J., and Melan, M.A.: Knockdown of RGS4and b-tubulin in CHO Cells Expressing the Human MT1 Melatonin Receptor Prevents Melatonin-induced Receptor Desensitization. Life Sciences 75: 2703-2715, 2004.
Radio, N.M., Doctor, J.S., and Witt-Enderby, P.A.: MT2 Melatonin Receptors and the MEK/ERK (1/2) Signaling Cascade Play a Role in Melatonin-induced Differentiation of Human Adult Mesenchymal Stem Cells into Osteoblasts, Journal of Pineal Research 40 (4): 332-342, 2006.
Surratt, C.K., Witt-Enderby, P.A., Johnson, D.A., Andersen, C.A., Bricker, J.D., Davis, V.L., Firestine, S.M., and Meng, W.M.: Development of a Neuroscience-oriented “Methods” Course for Graduate Students of Pharmacology and Toxicology. Cell Biology Education 5: 188-196, 2006.
Jarzynka, M.J., Passey, D.K., Ignatius, P.F., , Melan, M.A., Radio, N.M., Jockers, R., Rasenick, M.M., Brydon, L. and Witt-Enderby, P.A.: Modulation of Melatonin Receptors and G-protein Function by Microtubules, Journal of Pineal Research 41 (4): 324-336, 2006.
Attia, M.I., Julius, J Witt-Enderby, P.A., and Zlotos, D.P.: Synthesis and Pharmacological Evaluation of 13a, 14-dihydro-6H, 13H-pyrazino[1,2-a;4,5-a’]diindole analogs as potential melatonin receptor ligands, Tetrahedron, 63: 754-760, 2007.
Attia, M.I., Julius, J Witt-Enderby, P.A., and Zlotos, D.P.: Synthesis, NMR Conformational Analysis and Pharmacological Evaluation of 6,7, 13,14-tetrahydro-7aH-cyclobuta[2’,3’]indolo [2’,1’:2,3] pyrimido [1,2-a]indole analogs as potential melatonin receptor ligands, Organic and Biomolecular Chemistry, 5: 2129-2137, 2007.
Bondi, C.D., McKeon, R.M., Bennett, J.M., Ignatius, P.F., Brydon, L, Jockers, R., Melan, M.A., and Witt-Enderby, P.A.: MT1 melatonin receptor internalization underlies melatonin-induced morphologic changes in Chinese hamster ovary cells and these processes are dependent on Gi proteins, MEK 1/2 and microtubule modulation. J Pineal Res 44 (3): 288-298, 2008.
Attia, M.I. Witt-Enderby, P.A., and Julius, J.: Synthesis and pharmacological evaluation of pentacyclic 6a,7-dihydrodiindole and 2,3-dihydrodiindole derivatives as novel melatoninergic ligands. Bioorganic and Medicinal Chemistry, 16: 7654-7661, 2008.
Sethi, S., Adams, W., Pollock, J. and Witt-Enderby, P.A.: C-terminal Domains within Human MT1 and MT2 Melatonin Receptors are Involved in Internalization Processes. J Pineal Res, 45 (2): 212-218, 2008.
Jarzynka, M.J., Passey, D.K., Johnson, D.A., Konduru, N., Fitz, N., Radio, N.M., Rasenick, M., Benloucif, S. and Witt-Enderby, P.A. Microtubules Modulate Melatonin Receptors Involved in Phase-shifting Circadian Activity Rhythms: In vitro and in vivo evidence, J Pineal Res, 46 (2): 161-171, 2009.
Zlotos, D.P., Attia, M.I., Julius, J., Sethi, S. and Witt-Enderby, P.A.: 2-[(2,3-dihydro-1H-indol-1-yl)methyl]-melatonin Analogues: A novel class of MT2-selective melatonin receptor antagonists. J Med Chem, 52 (3): 826-833, 2009.
Markl, C., Attia, M.I., Julius, J., Sethi, S., and Witt-Enderby, P.A.: Synthesis and
Pharmacological Evaluation of 1,2,3,4-tetrahydropyrazino [1,2-a]indole and 2-[(phenylmethylamino)methyl]-1H-indole analogues as novel melatonergic lignads. Bioorganic Medicinal Chemistry, 2009 (in press: doi: 10.1016/j.bmc.2009.04.068).
Manuscripts in submission
Radio, N., Doctor, J., Jockers, R., and Witt-Enderby, P.A. MT2 Melatonin Receptors Scaffold To and Modulate Nuclear Translocation Patterns of MEK ½ and ERK ½ Following Chronic Melatonin Exposure and When Human Adult Mesenchymal Stem Cells Differentiate into Osteoblasts, Science.
Madura, J., Gorman, A., Li, P.K, Witt-Enderby, P.A., Chu, G.H.: Modeling of the Human mt1 Melatonin Receptor.
Peer-reviewed Abstracts
Lark, L., Witt, P., Becker, K., Studzinski, W., and Weyhenmeyer, J.A.: "Dietary Tryptophan Inhibits Dahl Salt-Induced Hypertension", Neuroscience Abstracts, 14: 974, 1988.
Witt, P.A., Davis, P., Kramer, T.H., and Burks, T.F.: "Role of Adrenergic and Purinergic Neurotransmission in Contraction of the Isolated Mouse Vas Deferens Preparation", FASEB Journal, 4: A977, 1990.
Witt, P.A., Kramer, T.H., and Burks, T.F.: "ATP and Norepinephrine are Synergistic in the Mouse Vas Deferens Preparation", The Pharmacologist, 32: 172, 1990.
Witt, P.A., Halonen, M., Yamamura, H.I., and Bloom, J.W.: M3 Muscarinic Receptor mRNA in Rabbit Tracheal Smooth Muscle", American Review Respiratory Disease, 143(4): A429, 1991.
Witt-Enderby, P.A., Bloom, J.W., Halonen, M., and Yamamura, H.I., "Chronic Exposure to the Beta2-Adrenoceptor Agonist, Albuterol, Decreases Beta- Adrenoceptor Affinity and Density in Rabbit Airways, American Review Respiratory Disease, 147: A176, 1993.
Witt-Enderby, P.A., Yamamura, H.I., Halonen, M., Palmer, J.D., and Bloom, J.W.: "Effect of Chronic Atropine Exposure on Airway Contraction and Muscarinic Receptors", American Review Respiratory Disease, 147: A173, 1993.
Witt-Enderby, P.A., and Dubocovich, M.L.: "Characterization and Regulation of a Human ML1A Melatonin Receptor Stably Expressed in CHO Cells", Neuroscience Abstracts, 21: 184, 1995.
Witt-Enderby, P.A., Masana, M.I., and Dubocovich, M.L.: "Pretreatment with Physiological Concentrations of Melatonin Resulted in a Supersensitization of Human ML1A Melatonin Receptor Signalling in Stably Transfected CHO Cells", FASEB J. 10(6): A1388, 1996.
Masana, M.I., Witt-Enderby, P.A., and Dubocovich, M.L., "Mechanisms Underlying Increases in Melatonin Receptor Density Following Melatonin Withdrawal", Neuroscience Abstracts, 22: 1400, 1996.
Dubocovich, M.L., Witt-Enderby, P.A., and Masana, M.I. “Affinity and Efficacy of Agonists, Partial Agonists, and Antagonists for the Human mel1a Melatonin Receptor Subtype.” The Pharmacologist, 39(1) : 68, 1997.
MacKenzie, R.S., Melan, M.A., and Witt-Enderby, P.A. “Melatonin’s Effects on Cell Morphology in an Ovarian Cell Line.” The Pharmacologist, 39(1) : 68, 1997.
Jones, M.P. and Witt-Enderby, P.A.. The Effect of Melatonin on Cellular Transformation in NIH3T3 Cells. Neuroscience Abstracts, 23: 1067, 1997.
Gillen, M.L., Li, P.K., Chu, G-H., Parekh, T.N., Johnson, D.A., and Witt-Enderby, P.A.: The Development of a Melatonin Receptor Affinity Label. Neuroscience Abstracts, 23: 1069, 1997.
MacKenzie, R.S., Melan, M.A., Hartman, H.B., and Witt-Enderby, P.A.: Melatonin Mediates Cytoskeletal Changes in an Ovarian Cell Line via the Mel1a Melatonin Receptor. Neuroscience Abstracts, 23: 609, 1997.
MacKenzie, R.S., Melan, M.A., and Witt-Enderby, P.A.: Melatonin-mediated Reorganization of Microtubules in Chinese Hamster Ovary Cells Transfected with the Human Mel1a Melatonin Receptor. Molecular Biology of the Cell, 8: 166a, 1997.
Takashima, Y., Witt-Enderby, P.A., and Clemens, J.W. Expression of Melatonin Receptors in Rat Ovarian Granulosa Cells. Molecular Biology of the Cell, 8: 452a, 1997.
Jarzynka, M.J. and Witt-Enderby, P.A. Mechanisms Underlying mt1 Melatonin Receptor Supersensitization Response. Neuroscience Abstracts, 25: 1457, 1999.
Witt-Enderby, P.A., Litten, E.E., McKeon, R.M., Bordt, S.L., and Melan, M.A. Neurites and Neurite-like Structures Induced in Neuronal and Non-neuronal Cells Following mt1 Melatonin Receptor Stimulation. Molecular Biology of the Cell, 10: 133a, 1999.
Seng, J.K, Witt-Enderby, P.A., and Thomas, S.P. Beta Adrenergic Receptor Characterization in the Pigeon Heart. FASEB J, 14: A159, 2000.
Witt-Enderby, P.A., Krawitt, B.J., Jarzynka, M.J., and Melan, M.A. Antisense Knock-down of Beta Tubulin in CHO Cells Expressing the Human mt1 Melatonin Receptor Has Opposing Effects on Melatonin Receptor Regulation. FASEB J., 14, A1354, 2000.
Witt-Enderby, P.A., Jarzynka, M.J., and Melan, M.A. Microtubules Modulate Melatonin Receptor Function. Neuoscience Abstracts (#277.18), 27: 142, 2001.
Bondi, D.C., Ignatius, P.F., Melan, M.A., McKeon, R. and Witt-Enderby, P.A. Internalization Events, Melatonin, EGF and MEK/ERK Underlie the Formation of Neurite-like Outgrowths in CHO Cells Expressing the Human MT1 Melatonin Receptor. Neuroscience Abstracts, Program no. 830.12, Abstract Viewer/Itinerary Planner, CD-ROM, 2002.
Radio, N., Petraglia, C., Doctor, J., and Witt-Enderby, P.A. The Effect of Melatonin on the Differentiation of Human Adult Stem Cells into Osteoblasts. Neuroscience Abstracts. Program no. 830.11, Abstract Viewer/Itinerary Planner, CD-ROM, 2002.
Pokala, V.N., Libertore, M.A., Zambon, N.J., Nagle, R.A., Li, P.K., Witt-Enderby, P.A., and Johnson, D.A. Effect of 192-IgG Saporin Medial-Septum Lesion on Hippocampal Receptor Density in Rats. Neuroscience Abstracts, Program no. 82.7, Abstract Viewer/Itinerary Planner, CD-ROM, 2002.
Witt-Enderby, P.A., Jarzynka, M.J., Krawitt, B.J. and Melan, M.A. Knock-down of Beta Tubulin or RGS4 Prevents MT1 Melatonin Receptor Desensitization. Neuroscience Abstracts, Program no. 512.1, Abstract Viewer/Itinerary Planner, CD-ROM, 2003.
Bondi, D.C., Melan, M.A., and Witt-Enderby, P.A. Further Characterization into the Role of Melatonin, EGF, Microtubules and MEK/ERK (1/2) in the Formation of Neurite-like Outgrowths in CHO Cells Expressing the Human MT1 Melatonin Receptor. Neuroscience Abstracts, Program no. 512.2, Abstract Viewer/Itinerary Planner, CD-ROM, 2003.
Konduru, N., D.C., Johnson, D.A., Liberatore, M.A., Benloucif, S., and Witt-Enderby, P.A. The Effect of Microtubules in Modulating Melatonin-mediated Phase Shifts of Circadian Activity Rhythms in Long Evans Rats. Neuroscience Abstracts, Program no. 510.7, Abstract Viewer/Itinerary Planner, CD-ROM, 2003.
Pokala, V.N., Witt-Enderby, P.A., and Johnson, D.A. Effect of Selective Cholinergic Lesion on the Septohippocampal Pathway on the Carbachol Stimulated GTPgS Binding in Rat Hippocampus. Neuroscience Abstracts, Program no. 799.7, Abstract Viewer/Itinerary Planner, CD-ROM, 2003.
Pokala, V.N., Fitz, N.F., Witt-Enderby, P.A., and Johnson, D.A. Septohippocampal Cholinergic Lesion on Alpha Secretase Activity in Rat Hippocampus. Neuroscience Abstracts, Program no. 846.14, Abstract Viewer/Itinerary Planner, CD-ROM, 2004.
Witt-Enderby, P.A., Bondi, C.D., and Melan, M.A. MT1 Melatonin Receptors, EGF Receptors and Intact Microtubules Modulate the Intracellular Translocation Patterns of Activated MEK but not ERK in CHO Cells Expressing the Human MT1 Melatonin Receptor. Neuroscience Abstracts, Program no. 963.14., Abstract Viewer/Itinerary Planner, CD-ROM, 2004.
Radio, N.M, Doctor, J.S., and Witt-Enderby, P.A. The Role of Melatonin, Melatonin Receptors and MEK/ERK (1/2) in Differentiating Human Mesenchymal Stem Cells into Osteoblasts. Neuroscience Abstracts, Program no. 963.15, Abstract Viewer/Itinerary Planner, CD-ROM, 2004.
Konduru, N.V., Johnson, D.A., Fitz, N.F., Benloucif, S., and Witt-Enderby, P.A. MT2 Melatonin Receptors and MEK/ERK (1/2) Modulate Melatonin-Mediated Phase Shifts of Circadian Activity Rhythms in Long Evans Rats. Neuroscience Abstracts, Program no. 195.10, Abstract Viewer/Itinerary Planner, CD-ROM, 2004.
Sethi, S., Adams, W. and Witt-Enderby, P.A. The Effect of C-terminal Tail Mutations on the Function and Internalization Patterns of MT1 and MT2 Melatonin Receptors Expressed in COS-7 Cells. Experimental Biology, Abstract # 172.1, 2006.
Radio, N., Doctor, J., Jockers, R., and Witt-Enderby, P.A. MT2 Melatonin Receptors Couple to Gi Protein, Beta Arrestin and MEK/ERK (1/2) in an Agonist-dependent Manner in Human Adult Mesenchymal Stem Cells Differentiated into Osteoblasts. Experimental Biology, Abstract #172.4, 2006.
Sethi, S., Radio, N, Jockers, R., Adams, W. and Witt-Enderby, P.A. Scaffolds Between MT2 Melatonin Receptors, Gi, Beta Arrestin, MEK and ERK Form in Differentiating Bone Stem Cells and These Processes Require Internalization; domains found to exist in the C-tail of the MT2 receptor. Experimental Biology, 2007.
Witt-Enderby, P.A., and Latimer, J.J. Melatonin Effects on Disease-free and Stage III Breast Tumor Cultures. University of Pittsburgh Cancer Institute Scientific Retreat, June 21-22, 2007
Kirker, R.M., Rea, S.L., Witt-Enderby, P.A., and Davis, V.L. Identification of Estrogen-Regulated Genes in the Lens Using ERd3 Transgenic Mouse Model with Inducible Cataracts. US-Japan Cooperative Cataract Research Group Meeting, Kailua-Kona, HI, Dec 2007.
Witt-Enderby, P.A., Julius, J, Attia, M.I., and Zlotos, D.P. The Pharmacological Evaluation of Novel and High-Affinity Melatonin Receptor Ligands. Experimental Biology Abstract # 724.9, 2008.
Sethi, S. and Witt-Enderby, P.A. Critical Time Periods of Melatonin Exposure Enhance Osteoblast Differentiation From Human Mesenchymal Stem Cells. Experimental Biology, Abstract # 782.12, 2008.
Witt-Enderby, P.A., Clafshenkel, W., King, T., Dodda, B., Kotlarczyk, M., Sethi, S., Rea, S., and Davis, V. Morinda citrifolia (noni) as an Alternative Medicine in the Prevention of Primary and Metastatic Breast Cancer in a HER2/neu Mouse Model. Experimental Biology Abstract #1136.1, 2008.
Witt-Enderby, P.A., Clafshenkel, W., King, T., and Davis, V. Morinda citrifolia (noni) as an Alternative Medicine in the Prevention of Primary HER2/neu Mammary Cancer in a Preclinical Model. University of Pittsburgh Cancer Institute Scientific Retreat, June 19-20, 2008
Participation in Meetings and unpublished Abstracts
Witt, P.A., Kramer, T.H., and Burks, T.F. "Role of Purinergic and Adrenergic Neurotransmission in Contraction of the Isolated Mouse Vas Deferens Preparation", Symposium on Inhibitory Amino Acids, Tucson, AZ., 1989.
Pals-Rylaarsdam, R., Xu, Y., Witt-Enderby, P.A., and Hosey, M.M.: "Site-directed Mutagenesis Reveals Domain Required for Phosphorylation and Desensitization of the m2 Muscarinic Acetylcholine Receptors, Chicago Signal Transduction Symposium, 1995.
Witt-Enderby, P.A. and Dubocovich, M.L.: "Characterization and Regulation of the Human ML1a Melatonin Receptor Stably Expressed in CHO Cells", Chicago Chapter Society for Neuroscience, 1995.
Witt-Enderby, P.A., Masana, M.I. and Dubocovich, M.L., Characterization of Human ML1a Melatonin Receptors in a Stable Cell Line, Pineal Cell Biology Gordon Conference, February, 1996.
Witt-Enderby, P.A., Masana, M.I., and Dubocovich, M.L., Characterization of Human ML1A Melatonin Receptors in a Stable Cell Line, Chicago Chapter Society for Neuroscience, 1996.
Masana, M.I., Witt-Enderby, P.A., and Dubocovich, M.L., "Mechanisms Underlying Increases in Melatonin Receptor Density Following Withdrawal of Melatonin", Chicago Signal Transduction Symposium, 1996.
Hudson, R.L., Masana, M.I., Witt-Enderby, P.A., Abraha, A., and Dubocovich, M.L. “Mechanism(s) of Human Melatonin Receptor Subtype Signalling in CHO Cells.” ACNP , Puerto Rico, December, 1996.
Li, P.K, Chu, G-H, and Witt-Enderby, P.A. “Synthesis and Receptor Binding Studies of Competitive and Affinity Labels of Melatonin Receptors”. American Chemical Society, San Francisco, CA, 1997.
Parekh, T.N., Li, P.K., Chu, G-H., Gillen, M.L., and Witt-Enderby, P.A.: “The Development of a Permanently Charged Melatonin Receptor Ligand”. The 13th Annual Graduate Medicinal Chemistry Meeting, Ann Arbor, MI, 1997.
Gillen, M.L., Li, P.K., Chu, G-H., Parekh, T.N., and Witt-Enderby, P.A.: “The Development of a Melatonin Receptor Affinity Ligand”. The 13th Annual Graduate Medicinal Chemistry Meeting, Ann Arbor, MI, 1997.
Takashima, Y., Witt-Enderby, P.A., and Clemens, J.W. Expression of Melatonin Receptors in Rat Ovarian Granulosa Cells In Vitro. 12th Annual Ovarian Workshop in Houston, TX, 1998.
Li, P.K., Sugden, D., Teh, M.T., Chu, G.H., Witt-Enderby, P.A., Synthesis and Studies of Irreversible Melatonin Receptor Ligands. Abstract #149. 218th National meeting of the American Chemical Society, Aug 22-26, 1999.
Witt-Enderby, P.A., McKeon, R.M., Litten, E.E., Bordt, S.L., and Melan, M.A., Neurites and Neurite-like Structures Induced in Neuronal and Non-neuronal Cells Following mt1 Melatonin Receptor Stimulation. G-protein Coupled Receptor Symposium. October 29-31, 2000.
Witt-Enderby, P.A. and Desselle, S.P. Evaluation of a CD-ROM Tutorial Reinforcing Concepts in Endocrinology, AACP Abstract, 2004.
Desselle, S.P., Mattei, T.J., Adeyeye, C., Giannetti, V.J., Harrold, M.W., O’Neil, C.K., Surratt, C.K., and Witt-Enderby, P.A. Quantifying Units of Production Among Pharmacy Academicians, AACP Abstract, 2004.
McFalls-Stringert., M.A., Mattei, T.J., and Witt-Enderby, P.A. Center for Pharmacy Practice Exercises: Integration, Reinforcement and the Enhancement of Learning, AACP Abstract, 2004.
Presentations
"Norepinephrine and ATP are Synergistic in the Mouse Vas Deferens Preparation", August 15, 1990, ASPET Meeting, Milwaukee, WI.
"ATP and Norepinephrine are Synergistic in the Mouse Vas Deferens Preparation", February 29, 1991, Graduate Program in Pharmacology and Toxicology, University of Arizona, Tucson, AZ.
"The Effect of Bronchodilators on Cholinergic Mechanisms Involved in Bronchial Responsiveness in Rabbit Lung", October 2, 1992, Graduate Program in Pharmacology and Toxicology, University of Arizona, Tucson, AZ.
"The Effect of Chronic Bronchodilator Therapy on Airway Responsiveness", March 10, 1993, Graduate Program in Pharmacology and Toxicology, University of Arizona , Tucson, AZ.
"Characterization and Regulation of the Human ML1a Melatonin Receptor Stably Transfected in CHO Cells", June 8, 1995, Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, IL.
"Regulation of the Human ML1a Melatonin Receptor Stably Transfected in CHO Cells", June 8, 1996, Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, IL.
“Characterization and Regulation of the Human mel1a Melatonin Receptor in a Stable Cell Line”, March 27, 1996, School of Pharmacy, Pittsburgh, PA.
“Characterization and Regulation of the Human mel1a Melatonin Receptor in a Stable Cell Line”, May 12, 1996, School of Pharmacy, Wilkes-Barre, PA.
“Characterization and Regulation of the Human mel1a Melatonin Receptor in a Stable Cell Line”, May 29, 1996, School of Pharmacy, Pomona, CA.
“Characterization and Regulation of the Human mel1a Melatonin Receptor in a Stable Cell Line”, March 19, 1997, Department of Medicinal Chemistry and Pharmaceutics, Duquesne University, Pittsburgh, PA.
“Characterization and Regulation of the Human mel1a Melatonin Receptor in a Stable Cell Line”, April 18, 1997, Department of Biological Sciences, Duquesne University, Pittsburgh, PA.
“Melatonin Receptors: Are they Really Unique Subtypes?” September 18, 1997, Pharmaceutical Sciences Seminar Series, Duquesne University, Pittsburgh, PA.
“Melatonin’s Effects on Cytoskeleton”, February 10, 1998, Allegheny General Neuroscience Institute, Allegheny General Hospital, Pittsburgh, PA.
“The Effects of Melatonin on Cellular Transformation, Proliferation and Morphology in NIH3T3 Cells Expressing Either the Human mt1 or MT2 Melatonin Receptor in a Stable Cell Line”, June 16, 1998, Magee Women’s Research Institute, Oakland, PA.
“Mechanisms Underlying Melatonin’s Effects on Cytoskeleton” March 22, 1999, Department of Cell Biology and Physiology and Center for Research in Reproductive Physiology, University of Pittsburgh, Oakland, PA.
“Melatonin Receptors and Their Involvement in Differentiation Processes” February 8, 2005, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Oakland, PA.
“Oral Contraceptives, Premenstrual Syndrome, Plan B and Drugs to treat Osteoporosis”, April 16, 2005, Hot Flash Conference, Clarion University, Clarion, PA.
“Use of Personal Response System (PRS) Keypads in the Classroom”, Turning Point Technologies Symposium, March, 2006, Duquesne University
“Signaling Mechanisms Underlying Melatonin’s Effects on Cellular Differentiation”, June 15, 2006, Center for Environmental Oncology, University of Pittsburgh, Oakland, PA.
“The Pharmacology of Pain Management with an Emphasis on Neuropathic Pain”, July 15, 2006, HospiceCare 2020 Conference, ProCare/Hospice Care, Atlanta, GA.
“Melatonin Receptor Signaling”, September 29, 2006, 2006 Symposium on Melatonin Receptors, University of Illinois at Chicago, Chicago, IL
“The Pharmacology of Pain Management”, November 9, 2006, Ohio Hospice and Palliative Care Organization Conference, Columbus, OH.
“Dr. Witt-Enderby’s Tips for Healthy Eating”, November 22, 2006, Kappa Epsilon Workshop, Duquesne University, Pittsburgh, PA
“Panel Presentation on Proposal for Blackboard User Group” March 5, 2007, Pittsburgh Blackboard Users Conference, Duquesne University, Pittsburgh, PA.
“Oral Contraceptives, Premenstrual Syndrome, Plan B and Drugs to treat Osteoporosis”, March 14, 2007, Kappa Epsilon Workshop, Duquesne University, Pittsburgh, PA.
“Melatonin Effects on Cellular Differentiation: the potential involvement of stem cells”, May 29, 2007, University of Pittsburgh, Center for Environmental Oncology, Pittsburgh, PA.
“The Effects of and Mechanisms Underlying Melatonin-induced Cellular Differentiation”, Febrauary 22, 2008, Department of Biology, Duquesne University, Pittsburgh, PA.
“Melatonin Signaling and Cellular Differentiation: potential targets for the prevention of osteoporosis and breast cancer”, August 10-15, 2008, Melatonin Receptors and Therapeutics, FASEB Summer Research Conference, Snowmass, CO
Collaborations
1994-1996, Ouahid Bakouche, Ph.D., Assistant Professor, Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, IL. The purpose of this collaboration was to determine if human monocytes could be activated by the pineal hormone melatonin and if human monocytes were expressing melatonin receptors.
1997-present, Melissa Melan, Ph.D., Assistant Professor, Department of Biological Sciences, Duquesne University, Pittsburgh, PA. The purpose of this collaboration is to determine the mechanisms underlying melatonin-induced changes in ovarian cell morphology.
1997-2003, Pui-Kai Li, Ph.D., Associate Professor, Department of Medicinal Chemistry and Pharmaceutics, Duquesne University, Pittsburgh, PA. The purpose of this collaboration is to develop melatonin analogues for both visualization of melatonin receptors and for internalization studies.
1997-2002, Jeff Clemens, Ph.D. Assistant Professor, Department of Biological Sciences, Duquesne University, Pittsburgh, PA. The purpose of this collaboration is to determine the role melatonin plays in the ovary.
2000-2005, John Doctor, Ph.D. Associate Professor, Department of Biological Sciences, Duquesne University, Pittsburgh, PA. The purpose of this collaboration is to determine the role of melatonin in human osteoblasts.
2001-2004, Andrjej Wieraszko, Ph.D. Professor, Department of Biology/Program in Neuroscience. The College of Staten Island, Staten Island, NY. The purpose of this collaboration is to determine the identity of the melatonin receptors in hippocampal evoked potentials in the mouse using two melatonergic ligands (BMNEP and TMEPI) developed by Dr Li and me.
2002-present, David Johnson, Ph.D., Associate Professor, Division of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA. The purpose of this collaboration is to determine the role of microtubules in circadian entrainment and memory.
2002-present, Susan Benloucif, Ph.D. Research Associate Professor, Northwestern University Medical School, Chicago, IL. The purpose of this collaboration is to determine the role of microtubules in circadian entrainment.
2003-2004, Chris Surratt, Ph.D. Associate Professor, Division of Pharmaceutical Sciences, Duquesne University. The purpose of this collaboration is to determine the domains involved with melatonin receptor regulation using site-directed mutatgenesis.
2003-present, Vicki Davis, Ph.D. Assistant Professor, Division of Pharmaceutical Sciences, Duquesne University. The purpose of this collaboration is to determine the role that melatonin plays in breast cancer.
2002-2006, Mark Rasenick, Ph.D. Professor of Physiology and Biophysics, Professor Psychiatry, Director of the Biomedical Neuroscience Training Program, University of Illinois at Chicago, Chicago, IL. The purpose of this collaboration is to assess the role of microtubules in G-protein activation by GTP exchange mechanisms.
2002-present, Ralf Jockers, Ph.D. Department of Cell Biology, Institut Cochin, Paris, France. The purpose of this collaboration was to determine the role of microtubules in modulating the coupling of MT1 melatonin receptors to G-proteins.
2003-present, David Earnest, Ph.D., Department of Human Anatomy and Medical Neurobiology, Texas A&M University Health Science Center, College Station, TX. The purpose of this collaboration is to assess the role of melatonin receptors in SCN 2.2 cells.
2005-2006, Phillip LeDuc, Ph.D., Department of Mechanical Engineering, Carnegie Mellon University, Oakland, PA. The purpose of this collaboration is to assess the translocation of kinases within a cell using fluidic channel and quantum dots.
2006-present, Darius Zlotos, Ph.D., Institut fur Pharmazie und LLMC, University of Wurzburg, Wurzburgh, Germany. The purpose of this collaboration is to develop novel and subtype-selective melatonin receptor ligands.
2006-present, Jean Latimer, Ph.D. University of Pittsburgh, Hillman Cancer Institute, Pittsburgh, PA. The purpose of this collaboration is to understand the role of melatonin on human stem cells taken from disease-free breast tissue or breast tumors as it relates to differentiation processes.
2007-present, Partha Basu, Ph.D., Associate Professor, Department of Chemistry and Biochemistry, Duquesne University. The purpose of this collaboration is to determine the mechanisms underlying arsenical action in the body.